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In one study in mice, large amounts of allopurinol caused birth defects and other unwanted effects. Do not use this medication if you are allergic to didanosine, or if you are also taking allopurinol (Zyloprim) or ribavirin (Rebetol, Ribasphere, Copegus Virazole). Allopurinol will not relieve a gout attack that has already started. You will need to discuss the benefits and risks of using Allopurinol while you are pregnant. The authors believed quinidine caused Henoch-Schonlein purpura in this patient based on a chronologic association and lack of allopurinol-associated problems following chronic therapy. Up to 300 milligrams (mg) of allopurinol can be taken at one time.

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